2011 Fiscal Year Final Research Report
Facile Synthesis of Glycoconjugate based on Direct Synthesis of Glycosyl Azide in Water
| Project/Area Number |
22850010
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
TANAKA Tomonari 京都工芸繊維大学, 工芸科学研究科, 助教 (70585695)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 糖鎖高分子 / オリゴ糖 / クリックケミストリー / 無保護 / 脱水縮合剤 |
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| Research Abstract |
It is very difficult to prepare glycoconjugates with oligosaccharide by chemical synthesis because it necessitates laborious tasks including protection and deprotection of hydroxy groups. Then, the facile method of glycoconjugates with oligosaccharide is demanded. In this research, I successfully developed the protecting-group-free addition of oligosaccharide by direct azidation of unprotected sugar and Click chemistry starting from unprotected sugar.
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[Journal Article] 4, 6-Dimethoxy-1, 3, 5-triazin-2-ylυ-D-glycosaminides : Novel Substrates for Transglycosylation Reaction Catalyzed by Exo-υ-D-glucosaminidase from Amycolatopsis orientalis
Author(s)
Tomonari Tanaka, Tomonori Wada, Masato Noguchi, Masaki Ishihara, Atsushi Kobayashi, Takayuki Ohnuma, Tamo Fukamizo, Ryszard Brzezinski, Shin-ichiro Shoda
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Journal Title
J. Carbohydr. Chem
Volume: (in press)
Peer Reviewed
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