2011 Fiscal Year Final Research Report
Biological function of novel adrenomedullin in vertebrates : a reverse-phylogenic approach
| Project/Area Number |
22870020
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphology/Structure
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| Research Institution | Okayama University |
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Principal Investigator |
OGOSHI Maho 岡山大学, 大学院・自然科学研究科, 助教 (00527997)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Tatsuya 岡山大学, 大学院・自然科学研究科, 教授 (10294480)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アドレノメデュリン / 脊椎動物 |
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| Research Abstract |
We have clarified that all five members of adrenomedullin(AM) family were expressed in tissues of medaka(Oryzias latipes) including osmoregulatory organs. The expressions of AM1, AM3, AM4 and AM5 were increased after transfer to freshwater and decreased in seawater, whereas that of AM2 was increased in seawater. The obtained data suggest that AM family genes except for AM2 are involved in freshwater adaptation, whereas AM2 is related to the adaptation to seawater.
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