2011 Fiscal Year Final Research Report
Molecular analysis for chromatin structure conserved beyond generations
| Project/Area Number |
22870038
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YOSHIDA Keisuke 独立行政法人理化学研究所, 石井分子遺伝学研究室, 基礎科学特別研究員 (80587452)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 次世代遺伝効果 / 自然免疫系 / マクロファージ / ATF-7 |
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| Research Abstract |
ATF-7 is reported to contribute to transgenerational effect of heat shock stress in fly. This time, I investigated molecular function of ATF-7 in innate immunity system using resident peritoneal macrophages. ChIP-chip results with ATF-7 antibody showed ATF-7 binds to promoter region of several tens of innate immunityrelated genes. At these sites, H3K9me2 level decrease and gene activity is enhanced in ATF-7 KO. I found that after treating macrophages by innate immune stress, ATF-7 binding and H3K9me2 level is decreased.
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