2011 Fiscal Year Final Research Report
Mechanism of high-density lipoprotein(HDL) formation by ABCA1
| Project/Area Number |
22880016
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
NAGAO Kohjiro 京都大学, 物質-細胞統合システム拠点, 研究員 (40587325)
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| Project Period (FY) |
2010 – 2011
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| Keywords | cholesterol / ABCA1 / HDL |
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| Research Abstract |
ABCA1 mediates the high-density lipoprotein(HDL) formation by loading cellular cholesterol onto apolipoproteinA-I(apoA-I). In this study, we analyzed the interaction between ABCA1 and apoA-I, which is first step of HDL formation. We showed that conformation of extracellular domain of ABCA1 is changed by ATP hydrolysis in nucleotide domain, and apoA-I binding site is produced by this conformation changes.
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