2011 Fiscal Year Final Research Report
Development of the synthetic method of glycoproteins with homogenous glycan structure oriented toward functional analysis of glycans
| Project/Area Number |
22880033
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 有機化学 / ペプチド化学 |
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| Research Abstract |
In this study, we tried to develop a novel thiol protecting group which was useful for protecting Cys side chain. As a result, Pocam group could be designed, synthesized and used for solid-phase peptide synthesis and peptide condensation reactions. On the other hand, we tried to synthesize neo-glycoproteins by the combination of bacterial recombinant protein expression system and in vitro glycosylation reaction. As a result, we could prepare a recombinant protein containing a specific functional group. A glycopeptide carrying S-linked glycan which was recently found as a novel post-translational modification was chemically synthesized.
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[Journal Article] Synthesis of the sphingolipid activator protein, Saposin C, using an azido-protected O-acyl isopeptide as an aggregation-disrupting element2011
Author(s)
Hironobu Hojo, Hidekazu Katayama, Chiharu Tano, Yuko Nakahara, Azusa Yoneshige, Junko Matsuda, Yohei Sohma, Yoshiaki Kiso, Yoshiaki Nakahara
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Journal Title
Tetrahedron Lett
Volume: 52
Pages: 635-639
Peer Reviewed
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