2011 Fiscal Year Final Research Report
Analysis of p3-Alc, metabolic product of Alcadein
| Project/Area Number |
22890001
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
HATA Saori 北海道大学, 大学院・薬学研究院, 助教 (40581012)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アルツハイマー病 |
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| Research Abstract |
To reveal the pathogenesis of sporadic type of Alzheimer's disease(AD), I analyzed AD-related peptide, p3-Alc, which is the metabolic product of Alcadein protein. In cerebrospinal fluid and blood of subjects with sporadic AD, p3-Alc peptides showed quality and quantity alteration. This result indicates that dysfunction of Alc-cleaving secretase can be acquired and it may link to the onset of sporadic AD.
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Research Products
(11 results)
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[Presentation] Alternativeγ-secretase processing in sporadic Alzheimer's disease suggested by p3-Alc peptide, metabolic product of Alcadein2011
Author(s)
Hata, S. Urakami, K., Taniguchi, M., Akatsu, H., Gandy, S., Suzuki, T
Organizer
Alzheimer's Association International Conference
Place of Presentation
Porte de Versailles(France)
Year and Date
20110716-21
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