2011 Fiscal Year Final Research Report
A role of alphaB-crystallin in angiogenesis of diabetic retinopathy
| Project/Area Number |
22890006
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KASE Satoru 北海道大学, 北海道大学病院, 医員 (60374394)
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| Project Period (FY) |
2010 – 2011
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| Keywords | alpha-crystallin / VEGF / 糖尿病網膜症 |
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| Research Abstract |
AlphaB-crystallin, a small heat shock protein, was expressed in CD31-positive microvessels of proliferative membranes in human diabetic retinopathy, whereas alphaB-crystallin was not expressed in normal retinal vessels, alphaB-crystallin expression was colocalized with VEGF immunoreactivity in proliferative membranes of diabetic retinopathy. Researches on alpha-crystallin toward retinal neovascularization leads to discovery of additional treatments with anti-VEGF therapy, whereby the therapeutic target is not direct VEGF protein itself, but a molecule regulating VEGF degradation.
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[Journal Article] WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing2011
Author(s)
Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, Welsh GI, Cheung MK, Ni L, Kase S, Rennel ES, Symonds KE, Nowak DG, Royer-Pokora B, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton DR, Bates DO, Ladomery MR.
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Journal Title
Cancer Cell
Volume: 20(6)
Pages: 768-80
DOI
Peer Reviewed
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