2011 Fiscal Year Final Research Report
DNA methylation analyses to predict the treatment outcome of advanced hepatoblastoma patients.
| Project/Area Number |
22890008
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
HONDA Shohei 北海道大学, 北海道大学病院, 医員 (90588089)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 肝芽腫 / DNAメチル化異常 / 予後予測分子マーカー |
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| Research Abstract |
To establish novel prognostic markers for advanced hepatoblastoma patients, we examined the methylation status of candidate tumor suppressor genes located in the shortest overlap region of deletion found in hepatoblastoma tumors detected by SNPs array analysis. Hypermethylation of a candidate gene was found in hepatoblastoma cell lines, although hepatoblastoma tumor samples did not show any aberration of the methylation status.
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