2011 Fiscal Year Final Research Report

Undersulfation of chondroitin sulfate and abnormal cartilage tissue by the signaling of the receptor of PTH/PTHrP

Research Project

Project/Area Number	22890009
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Orthodontic/Pediatric dentistry
Research Institution	Tsurumi University (2011) Hokkaido University (2010)
Principal Investigator	WADA Satoshi 鶴見大学, 歯学部, 学部助手 (20581119)
Project Period (FY)	2010 – 2011
Keywords	コンドロイチン硫酸の低硫酸化 / PTH/PTHrPシグナル / 細胞外基質合成異常
Research Abstract	The objectives of this study are to elucidate the relationship between not only differentiation of chondrocytes and extracellular matrix, but also proliferation of them. We performed immunohistochemical analysis in cartilage of the spheno-occipital synchondrosis of BALB/c-bm/bm mice. The expression of collagen II and collagen X were expressed irregularly in the spheno-occipital synchondrosis. Additionally, the expression of alkaline phosphatase was expressed in the center of the spheno-occipital synchondrosis, whereas that of the PCNA was expressed around the spheno-occipital synchondrosis. In summary, these results presented that the differentiation of hypertrophic chondrocytes was enhanced in the center of the spheno-occipital synchondrosis, whereas the proliferation of chondrocytes was increased around the spheno-occipital synchondrosis.

(2 results)