2011 Fiscal Year Final Research Report
Investigation of the gender difference in the intestinal cholesterol absorption for the development of personalized therapy in dyslipidemia
| Project/Area Number |
22890033
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 発現制御 / 消化管吸収 / 胆汁 |
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| Research Abstract |
Niemann-Pick C1 like 1(NPC1L1) is known to play an important role in the intestinal cholesterol absorption and biliary cholesterol re-absorption. In the present study, we revealed that mRNA expression of NPC1L1 is increased by female hormone(estrogen) in estrogen receptorα(ERα)-expressing cells. In addition, we found the novel function of NPC1L1 as a negative regulator of protein expression and secretion of Niemann-Pick C2(NPC2), which controls intracellular cholesterol trafficking and promotes biliary cholesterol secretion. These results would be important to consider the relationship between the gender difference in the expression level of NPC1L1 and the benefit of treatment for dyslipidemia.
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