Investigation of involvement of chemokines and chemokine receptors in cutaneous lymphoma

2011 Fiscal Year Final Research Report

• Project/Area Number: 22890044
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: MIYAGAKI Tomomitsu 東京大学, 医学部附属病院, 助教 (50582003)
• Project Period (FY): 2010 – 2011
• Keywords: 皮膚悪性リンパ腫 / CCL11 / オートクリン / cell survival / CCL20 / CCL18 / disease marker / 微小環境

Research Abstract

CCL11. CCR3 interactions induce cell survival and proliferation of CCR3+anaplastic large cell lymphoma cells through constitutive phosphorylation of ERK1/2. Interactions of CCL11 and CCR3 may be a promising target for the development of future therapies for anaplastic large cell lymphoma. CCL20 and CCL18 expression is elevated in lesional skin and serum of mycosis fungoides and Sezary syndrome, and they correlated with disease severity markers of these diseases.

Research Products

• [Journal Article] IL-22, but not IL-17, Dominant Environment in Cutaneous T cell Lymphoma (2011)
  • Author(s): Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
  • Journal Title: Clin Cancer Res Volume: 17巻 Pages: 7529-7538
  • Peer Reviewed
• [Journal Article] Eotaxin-CC Chemokine Receptor 3 Interactions Promote Survival of Anaplastic Large Cell Lymphoma Cells via ERK1/2 Activation (2011)
  • Author(s): Miyagaki T, Sugaya M, Murakami T, Asano Y, Tada Y, Kadono T, Okochi H, Tamaki K, Sato S
  • Journal Title: Cancer Res Volume: 71巻 Pages: 2056-2065
  • Peer Reviewed
• [Journal Article] Increased CCL18 expression in patients with cutaneous T cell lymphoma : association with disease severity and prognosis
  • Author(s): Miyagaki T, Sugaya M, Suga H, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
  • Journal Title: J Eur Acad Dermatol Venereol
  • Peer Reviewed
• [Presentation] IL-22, but not IL-17, Dominant Environment in Cutaneous T cell Lymphoma (2012)
  • Author(s): Miyagaki T
  • Organizer: The 72^<nd> Annual Meeting of the Society for Investigative Dermatology. Raleigh, NC
  • Place of Presentation: Raleigh, NC, USA
  • Year and Date: 2012-05-10
• [Presentation] Eotaxin-CCR3 interaction promotes survival of anaplastic large cell lymphoma cells via ERK1/2 activation (2010)
  • Author(s): Miyagaki T
  • Organizer: The 70^<th> Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 2010-05-06