2011 Fiscal Year Final Research Report
Basic Study of functionality and cell differentiation of decidual macrophages targeting the development of novel clinical approach for the prediction and the therapy of preterm delivery.
| Project/Area Number |
22890045
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 早産 / マクロファージ / 脱落膜 / 免疫 |
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| Research Abstract |
This study aimed to investigate the relevance of decidual macrophages in the pathology of preterm delivery. We clarified that decidual macrophages have unique immunological property that promotes maternal tolerance to fetal antigen mediated by humoral factors and direct cell-to-cell interaction. Our finding proposed that this anti-inflammatory property might act as a negative factor upon preterm delivery, leading to the progression of intrauterine infection. In the analysis using mouse model, functional switching of macrophages to pro-inflammatory phenotype occurs upon intrauterine infection. The suppression of this phenotypical shift using anti-inflammatory substance can be a new strategy for the treatment of preterm delivery.
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