2011 Fiscal Year Final Research Report
Establishment of novel melanoma model mice with humanized mouse skin and analysis of their melanoma genesis mechanisms
| Project/Area Number |
22890048
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | メラノーマ / モデル動物 / 色素幹細胞 / 実験病理学 / NRAS遺伝子 / BRAF遺伝子 / SCF遺伝子 / Ink4a/ARF遺伝子 |
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| Research Abstract |
Malignant Melanomas is representative treatment resistant tumor, and the generating mechanism is not clarified yet, therefore, it waits for mechanism elucidation. We have successfully generated the novel mice model by combination with humanized mouse skin and genetic manipulations. Now, we are analyzing the melanoma genesis mechanism in detail by using their novel model
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