2011 Fiscal Year Final Research Report
Establishment for rat model of sporadic amyotrophic lateral sclerosis
| Project/Area Number |
22890051
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OHKUBO Takuya 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (90587461)
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| Co-Investigator(Renkei-kenkyūsha) |
YOKOTA Takanori 東京医科歯科大学, 大学院・医歯学総合研究科脳神経病態学, 教授 (90231688)
UCHIHARA Toshiki 東京都医学総合研究所, 脳病理形態研究室, 室長 (10223570)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 筋萎縮性側索硬化症(ALS) / ラットモデル / TDP-43 |
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| Research Abstract |
Amyotrophic lateral sclerosis(ALS) is a fatal neurodegenerative disease characterized by progressive motor paresis. Recently transactive response DNA-binding protein 43(TDP-43) was newly identified as one of the targeted protein of sporadic ALS, however, their significance has not been fully elucidated. We succeeded in establishment for rat model of sporadic ALS by the method of overexpressing wild-type of human TDP-43 in spinal cords of rats by injecting adeno-associated virus vector into their cervical cords. Our animal models will provide a valuable tool for studying the pathogenesis of sporadic ALS.
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[Journal Article] Non-human primate model of ALS with cytoplasmic mislocalizaion of TDP-43. Brain2012
Author(s)
Uchida A, Sasaguri H, Kimura N, TajiriM, Ono F, Ohkubo T, Sakaue F, Kanai K, Hirai T, Sano T, Shibuya K, Kobayashi M, Ueno T, Yamamoto M, Kubodera T, Tomori M, Sakaki K, Enomoto M, HiraiY, Yasutomi Y, Mochizuki H, Uchihara T, Kuwabara S, Mizusawa H, Yokota T.
Volume
135
Pages
833-46
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