2011 Fiscal Year Final Research Report
Pathophysiological role of macrophages in development of NASH
| Project/Area Number |
22890052
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ITO Michiko 東京医科歯科大学, 難治疾患研究所, 寄附研究部門教員 (00581860)
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| Project Period (FY) |
2010 – 2011
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| Keywords | NASH / 肝細胞癌 / 肥満 / 慢性炎症 / マクロファージ |
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| Research Abstract |
Non-alcoholic steatohepatitis(NASH) is considered a hepatic phenotype of metabolic syndrome and at high risk for the progression to cirrhosis and hepatocellular carcinoma. The molecular mechanisms are still unclear partly because of no appropriate animal models that reflect a liver condition similar to human NASH. In this study, we showed that MC4R-KO mice on a high-fat diet would provide a novel mouse model of NASH with which to investigate the sequence of events that comprise diet-induced hepatic steatosis, liver fibrosis, and hepatocellular carcinoma. Using this mouse model, we found changes in macrophage distribution and function during the course of NASH development.
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