2011 Fiscal Year Final Research Report
The imaging analysis of molecules that regulate neuronal polarity
| Project/Area Number |
22890061
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Niigata University |
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Principal Investigator |
INUTSUKA Ayumu 新潟大学, 医歯学総合研究科, 研究員 (30584776)
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| Co-Investigator(Renkei-kenkyūsha) |
KISHI Masashi 新潟大学, 医歯学系, 准教授 (60573938)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経極性 / イメージング / SADキナーゼ / 細胞骨格 |
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| Research Abstract |
To identify new downstream elements of SAD kinase which is known to regulate neuronal polarity, we undertook screening and identified several candidate molecules. One of them is strongly enriched in the central nervous system, and we named it BrancK after its function on neurite branching. Elevation of BrancK activity in primary hippocampal neurons promoted neurite branching, and we found that BrancK was enriched at the sites where new microspikes emerged along neurites. Consistent with these findings, BrancK KO mouse showed reduced neurite arborization.
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