2011 Fiscal Year Final Research Report
study of molecular mechanism of catechin on degradative effect of growth factor receptor and suppressive effect of tumor growth
| Project/Area Number |
22890074
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 癌 / シグナル伝達 / 蛋白質 |
|---|
| Research Abstract |
Pletelet derived growth factor receptor(PDGFR) is one of the molecule target for cancer treatment. Cathechin has an anti-tumor effect, and we examined the effect for PDGFR. PDGFR protein was decreased by EGCG treatment. The decrease was promoted by the inhibitor of protein synthesis, and suppressed by the inhibitor of protein degradation. PDGFR ubiquitinization was observed by the treatment with EGCG and inhibitor of protein degradation. It was suggested that PDGFR protein was decrease by EGCG treatment through the activation of ubiquitin-proteasome pathway.
|
