2011 Fiscal Year Final Research Report
The role of HER2 in Rheumatoid Arthritis therapy
| Project/Area Number |
22890076
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
ANDO Takashi 山梨大学, 医学工学総合研究部, 助教 (10377492)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 関節リウマチ / 滑膜 / HER2 / 関節炎モデルマウス / 抗HER2抗体 |
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| Research Abstract |
Approved by the Ethics Committee in the University of Yamanashi, human synovial membrane was collected as a sample of Rheumatoid Arthritis patient on Total Knee Arthroplasty. Although there is a tendency of high expression of HER2 in rheumatoid arthritis synovial membrane samples, have yet to get a significant difference from control group. After anti-HER2 antibody(trastuzumab) treatment, the effect of suppressing synovial cell proliferation was confirmed by WST assay and the appearance of apoptotic cells were detected by FACS analysis.
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Fujita K, Ando T, Ohba T, Wako M, SatoN, Nakamura Y, Ohnuma Y, Hara Y, Kato R, Nakao A, Haro H
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