2010 Fiscal Year Final Research Report
Mechanism of Cardiac Release and Uptake of MicroRNAs:The Role in Cardiac Pathophysiology
| Project/Area Number |
22890090
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
NISHI Hitoo Kyoto University, 医学研究科, 研修員 (70583194)
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| Project Period (FY) |
2010
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| Keywords | MicroRNA / エクソソーム / 虚血性心疾患 |
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| Research Abstract |
Serum levels of cardiac specific microRNAs in patients with ischemic heart disease were quantified by real-time PCR and consequently, miR-1 and miR-133a were found to be up-regulated. It was also demonstrated that A23187 could increase microRNA levels in the culture medium of H9C2 rat myoblast cells in a dose-dependent manner, and microRNAs contained in exosomes might be incorporated into cells and function in the recipient cells.
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