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2011 Fiscal Year Final Research Report

New tuberculosis lipid antigen vaccine using rhesus infection model.

Research Project

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Project/Area Number 22890091
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Infectious disease medicine
Research InstitutionKyoto University

Principal Investigator

KUWATA Hirotaka  京都大学, ウイルス研究所, 助教 (60380523)

Project Period (FY) 2010 – 2011
Keywords免疫学 / 微生物学 / 感染症 / 細菌
Research Abstract

New development for anti-TB vaccination based on lipid chemistry has been eagerly expected. Mycobacterial mycolates were evaluated and confirmed for their ability to induce specific responses as therapeutic agents in Rhesus macaque vaccine model. As the results, mycolates augmented the specific induction of IFN-gamma from lymphocyte derived from peripheral blood. Taken together, it is validated that Mycobacterium mycolate can be a strong candidate for anti TB vaccination.

  • Research Products

    (3 results)

All 2011

All Journal Article (2 results) Presentation (1 results)

  • [Journal Article] A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity.2011

    • Author(s)
      Komori T, Nakamura T, Matsunaga I, Morita D, Hattori Y, Kuwata H, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
    • Journal Title

      J Biol Chem.

      Volume: 286 Pages: 13

  • [Journal Article] Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function.2011

    • Author(s)
      Jaqaman K, Kuwata H, Touret N, Collins R, Trimble WS, Danuser G, Grinstein S.
    • Journal Title

      Cell

      Pages: 146

  • [Presentation] Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function.2011

    • Author(s)
      桑田啓貴, Grinstein S.
    • Organizer
      第40回日本免疫学会学術集会
    • Year and Date
      2011-11-27

URL: 

Published: 2013-07-31  

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