2011 Fiscal Year Final Research Report
New tuberculosis lipid antigen vaccine using rhesus infection model.
| Project/Area Number |
22890091
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 免疫学 / 微生物学 / 感染症 / 細菌 |
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| Research Abstract |
New development for anti-TB vaccination based on lipid chemistry has been eagerly expected. Mycobacterial mycolates were evaluated and confirmed for their ability to induce specific responses as therapeutic agents in Rhesus macaque vaccine model. As the results, mycolates augmented the specific induction of IFN-gamma from lymphocyte derived from peripheral blood. Taken together, it is validated that Mycobacterium mycolate can be a strong candidate for anti TB vaccination.
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