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2011 Fiscal Year Final Research Report

A novel organ preservation technique for small-for-size graft in liver transplantation : Venous Systemic Nitric Oxide with Oxygen Gaseous Persufflation.

Research Project

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Project/Area Number 22890094
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionKyoto University

Principal Investigator

YAGI Shintaro  京都大学, 医学研究科, 助教研究者 (60447969)

Project Period (FY) 2010 – 2011
Keywords過少グラフト / 一酸化窒素 / 生体肝移植 / 門脈血流 / 臓器保存 / 酸素
Research Abstract

Anitric oxide(NO) with oxygen gaseous persufflation is a novel and safe preservation method for small-for-size graft liver transplantation, not only alleviating graft injury via anti-inflammatory conditions, but also improving microcirculation and bileductule damage.

  • Research Products

    (23 results)

All 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (14 results)

  • [Journal Article] Impact of venous systemic oxygen persufflation supplemented with nitric oxide gas on cold stored warm ischaemia-damaged experimental liver grafts2012

    • Author(s)
      Srinivasan K, Yagi S(5人略2番目)
    • Journal Title

      Liver Transpl

      Volume: 18巻 Pages: 219-225

    • DOI

      DOI:10.1002/lt.22442

    • Peer Reviewed
  • [Journal Article] Standard of hepatic vein reconstruction with patch plasty using native portal vein in adult living donor liver transplantation2012

    • Author(s)
      Mori A, Yagi S(8人略6番目)
    • Journal Title

      Liver Transpl

      Volume: 17巻(In press)

    • DOI

      DOI:10.1002/lt.23387

    • Peer Reviewed
  • [Journal Article] Effects of Post-transplant Enteral Nutrition with an Immunomodulating Diet Containing Hydrolyzed Whey Peptide after Liver Transplantation2012

    • Author(s)
      Kaido T, Yagi S(5人略6番目)
    • Journal Title

      World J Surg

      Volume: (In press)

    • DOI

      DOI:10.1007/s00268-012-1529-9

    • Peer Reviewed
  • [Journal Article] Living donor liver transplantation for recurrent hepatocellular carcinoma after liver resection2012

    • Author(s)
      Kaido T, Yagi S(6人略7番目)
    • Journal Title

      Surgery

      Volume: 151巻 Pages: 55-60

    • DOI

      DOI:10.1016/j.surg.2011.06.032

    • Peer Reviewed
  • [Journal Article] Lower limit of the graft-to-recipient weight ratio can be safely reduced to 0. 6% in adult-to-adult living donor liver transplantation in combination with portal pressure control2011

    • Author(s)
      Kaido T, Yagi S(6人略7番目)
    • Journal Title

      Transplant Proc

      Volume: 43巻 Pages: 2391-93

    • DOI

      DOI:10.1016/j.surg.2011.06.032

    • Peer Reviewed
  • [Journal Article] Oral application of 1, 7-dimethylxanthine(paraxanthine) attenuates the formation of experimental cholestatic liver fibrosis2011

    • Author(s)
      Klemmer I, Yagi S, Gressner OA
    • Journal Title

      Hepatol Res

      Volume: 41巻 Pages: 1094-1109

    • DOI

      DOI:10.1111/j.1872-034X.2011.00856.x

    • Peer Reviewed
  • [Journal Article] Improved preservation and microcirculation with POLYSOL after partial liver transplantation2011

    • Author(s)
      Yagi S, Doorschodt B. M, Afify M, Uemoto S, Tolba R
    • Journal Title

      Journal of surgical research

      Volume: 167巻 Pages: 375-383

    • DOI

      DOI:10.1016/j.jss.2010.12.040

    • Peer Reviewed
  • [Journal Article] Posttransplant bacteremia in adult living donor liver transplant recipients2011

    • Author(s)
      Iida T, Yagi S(7人略、3番目)
    • Journal Title

      Liver Transpl

      Pages: 1379-85

    • DOI

      DOI:10.1002/lt.22165

    • Peer Reviewed
  • [Journal Article] Comprehensive and innovative techniques for liver transplantation in rats : a surgical guide2010

    • Author(s)
      Hori T, Yagi S(31人中6番目)
    • Journal Title

      World J Gastroenterol

      Pages: 3120-32

    • DOI

      DOI:10.3748/wjg.v16.i25.3120.

    • Peer Reviewed
  • [Presentation] 肝移植術前感染症合併例に対する至適移植時期の検討2011

    • Author(s)
      八木真太郎
    • Organizer
      JDDW 2011(第9回消化器外科大会)
    • Place of Presentation
      福岡国際センター他(福岡県)
    • Year and Date
      2011-10-23
  • [Presentation] 肝移植術前感染症合併例の解析と至適移植時期の検討2011

    • Author(s)
      八木真太郎
    • Organizer
      第66回日本消化器外科総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-23
  • [Presentation] A novel organ preservation technique for small-for-size grafts in liver transplantation : Venous Systemic Oxygen Persufflation.(VSOP)+Nitric Oxide Gas.2011

    • Author(s)
      Yagi S
    • Organizer
      2011 International Liver Transplant Society
    • Place of Presentation
      (ヴァレンシア)スペイン
    • Year and Date
      2011-06-24
  • [Presentation] 心停止ドナー肝移植に対する酸素を用いた臓器保存VSOPの効果-ドナープール拡大を目指して2011

    • Author(s)
      八木真太郎
    • Organizer
      第23回肝胆膵外科学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-06-08
  • [Presentation] A novel organ preservation technique for small-for-size grafts in liver transplantation : Venous Systemic Oxygen Persufflation.(VSOP)+Nitric Oxide.2011

    • Author(s)
      Yagi S
    • Organizer
      46th European Society Surgical Research
    • Place of Presentation
      (アーヘン)ドイツ
    • Year and Date
      2011-05-27
  • [Presentation] 生体肝移植ドナーにおける門脈分岐様式が胆管合併症に及ぼす影響についてー胆管分岐形態の検討から2011

    • Author(s)
      八木真太郎
    • Organizer
      第111回日本外科学会
    • Year and Date
      2011-05-26
  • [Presentation] oxygen free radicalが肝small-for-size graftに対する影響について2010

    • Author(s)
      八木真太郎
    • Organizer
      第46回日本移植学会総会
    • Place of Presentation
      (みやこめっせ)京都府
    • Year and Date
      2010-10-20
  • [Presentation] Improved preservation and microcirculation with POLYSOL after small-for-size liver transplantation in rats2010

    • Author(s)
      Yagi S
    • Organizer
      8th Japan-Korea Transplantation Forum
    • Place of Presentation
      (みやこめっせ)京都府
    • Year and Date
      2010-10-20
  • [Presentation] ラットsmall-for-size graft肝移植モデルにおける新しい臓器保存液POLYSOLの影響.虚血再灌流障害並びに肝再生の観点から2010

    • Author(s)
      八木真太郎
    • Organizer
      JDDW2010(第8回日本消化器外科学会大会)
    • Place of Presentation
      (みなとみらい横浜)神奈川県
    • Year and Date
      2010-10-16
  • [Presentation] 門脈圧制御による過少グラフト肝移植治療戦略.グラフト重量の限界へ2010

    • Author(s)
      八木真太郎
    • Organizer
      第17回日本門脈圧亢進症学会
    • Place of Presentation
      (富山国際会議場)富山県
    • Year and Date
      2010-09-09
  • [Presentation] Impact of Oxygen Free Radicals on Liver Graft Microcirculation and Function after Partial Liver Transplantation in Rats2010

    • Author(s)
      Yagi S
    • Organizer
      2010 International Liver Transplant Society
    • Place of Presentation
      (香港)中華人民共和国
    • Year and Date
      2010-06-16
  • [Presentation] Impact of N-acetyl cysteine on liver graft microcirculation and function after partial liver transplantation in rats2010

    • Author(s)
      Yagi S
    • Organizer
      45th European Society for Surgical Research Congress
    • Place of Presentation
      (ジュネーブ)スイス
    • Year and Date
      2010-06-12
  • [Presentation] Impact of nitric oxide gaseous persufflation during cold storage on the liver grafts from NHBD in rats2010

    • Author(s)
      Kadaba P
    • Organizer
      45th European Society for Surgical Research Congress
    • Place of Presentation
      (ジュネーブ)スイス
    • Year and Date
      2010-06-12
  • [Presentation] Improved preservation and microcirculation with POLYSOL after small-for-size liver transplantation in rats2010

    • Author(s)
      Yagi S
    • Organizer
      American Transplant Congress
    • Place of Presentation
      (サンディエゴ)アメリカ合衆国
    • Year and Date
      2010-05-02

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Published: 2013-07-31  

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