Studies on transcriptional regulation and function of a novel adipokine, D-dopachrome tautomerase

2011 Fiscal Year Final Research Report

• Project/Area Number: 22890124
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: ISHIMOTO Kyoko 徳島大学, 病院, 助教 (60579952)
• Project Period (FY): 2010 – 2011
• Keywords: 前駆脂肪細胞 / DDT / CD74 / ERK / IL-6 / 脂肪細胞分化 / 転写調節

Research Abstract

D-dopachrome tautomerase(DDT), a novel adipokine, induces mRNA expression of IL-6 in preadipocytes. The DDT-induced IL-6 expression was found to be mediated by CD74. DDT impaired adipogenesis by inhibiting mRNA induction of adipogenic regulators during adipogenesis. Furthermore, the DDT promoter region involved the transcription in adipocytes was identified.

Research Products

• [Journal Article] The action of D-dopachrome tautomerase as an adipokine in adipocyte lipid metabolism (2012)
  • Author(s): Iwata T, Taniguchi H, Kuwajima M, Taniguchi T, Okuda Y, Sukeno A, Ishimoto K, Mizusawa N, Yoshimoto K.
  • Journal Title: PLoS One Volume: Vol.7, No.2 Pages: e33402
  • DOI: DOI:10.1371/journal.pone.0033402
  • Peer Reviewed
• [Journal Article] 新規アディポカインD-dopachrome tautomeraseの前駆脂肪細胞における機能解析 (2011)
  • Author(s): 石本恭子
  • Journal Title: 四国歯学会雑誌 Volume: Vol.1, No.1 Pages: 1-17
• [Journal Article] Compressive force inhibits adipogenesis through COX-2-mediated down-regulation of PPARγ2 and C/ EBPα (2010)
  • Author(s): Md. Golam Hossain, Takeo Iwata, Noriko Mizusawa, Schadan Wan Nazatul Shima, Toru Okutsu, kyoko Ishimoto, Katsuhiko Yoshimoto
  • Journal Title: Journal of Bioscience and Bioengineering Volume: Vol.109, No.3 Pages: 297-303
  • DOI: DOI:10.1016/j.jbiosc.2009.09.003
  • Peer Reviewed
• [Presentation] D-dopachrome tautomeraseは肥満マウスでのインスリン抵抗性を改善する (2011)
  • Author(s): 岩田武男
  • Organizer: 第53回歯科基礎医学会学術大会
  • Place of Presentation: 長良川国際会議場(岐阜)
  • Year and Date: 2011-10-02
• [Presentation] Functional analysis of a novel adipokine, D-dopachrome tautomerase, in preadipocytes (2010)
  • Author(s): 石本恭子
  • Organizer: International Joint Symposium : The University of Tokushima, Universitas Gadjah Mada, Niigata University
  • Place of Presentation: インドネシアデンパサール
  • Year and Date: 20101217-18
• [Presentation] 前駆脂肪細胞における新規アディポカインD-dopachrome tautomeraseの作用解析 (2010)
  • Author(s): 石本恭子
  • Organizer: 第69回日本矯正歯科学会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 20100927-29
• [Presentation] D-dopachrome tautomeraseが脂肪分化に及ぼす影響 (2010)
  • Author(s): 石本恭子
  • Organizer: 第52回歯科基礎医学会学術大会・総会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 20100920-22
• [Presentation] D-dopachrome tautomeraseは脂肪細胞での中性脂肪量を制御する (2010)
  • Author(s): 岩田武男
  • Organizer: 第52回歯科基礎医学会学術大会・総会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 20100920-22
• [Presentation] 新規アディポカインD-dopachrome tautomeraseの抗肥満作用についての検討 (2010)
  • Author(s): 石本恭子
  • Organizer: 第10回日本内分泌学会四国支部学術集会
  • Place of Presentation: 徳島大学病院(徳島)
  • Year and Date: 2010-09-04