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2011 Fiscal Year Final Research Report

Is resistin a novel modulator of periodontits?

Research Project

  • PDF
Project/Area Number 22890126
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

MURATA Hiromi  徳島大学, 病院, 医員 (00583874)

Project Period (FY) 2010 – 2011
Keywordsレジスチン / 歯周炎 / 糖尿病
Research Abstract

The aim of this study is investigate a role of resistin, an adipocytokine related to diabetes mellitus(DM), in periodontitis. When resistin level in gingival crevicular fluid(GCF) was examined, reisitin level in GCF samples from periodontitis and DM-related periodontitis was higher than that of healthy sites. Lipopolysaccharide of P. gingivalis(P-LPS) increased a release of resistin from human neutrophils and its induction was inhibited with actin polymerization inhibitors. In contrast, advanced glycation end-products(AGEs) and P-LPS did not clearly affect on resistin expression in human macrophages derived from the U937 cell line. The present result shows resistin may modulate an inflammation in periodontal diseases.

  • Research Products

    (5 results)

All 2012 2011

All Journal Article (1 results) Presentation (4 results)

  • [Journal Article] Resistin in gingival crevicular fluid and induction of resistin release by Porphyromonas gingivalis lipopolysaccharide in human neutrophils2012

    • Author(s)
      Hiroshima Y, Bando M, Inagaki Y, Mihara C, Kataoka M, Murata H, Shinohara Y, Nagata T, Kido J.
    • Journal Title

      J Periodontal Res

      Volume: (in press)

    • DOI

      DOI:10.1111/j.1600-0765.2011.01466.x

  • [Presentation] バイオマーカーを用いた糖尿病関連歯周炎の診断研究2012

    • Author(s)
      木戸淳一, 稲垣裕司, 板東美香, 廣島佑香, 村田裕美, 美原智恵, 堀部ますみ, 米田哲, 二宮雅美, 大石慶二, 坂本英次郎, 中島由紀子, 生田貴久, 浅原洋士, 永田俊彦
    • Organizer
      第28回歯科医学を中心とした総合的な研究を推進する集い
    • Place of Presentation
      東京(歯科医師会館)
    • Year and Date
      2012-01-07
  • [Presentation] 最終糖化産物はマクロファージ様細胞の炎症関連因子の発現を調節する2011

    • Author(s)
      村田裕美, 木戸淳一, 板東美香, 廣島佑香, 稲垣裕司, 永田俊彦
    • Organizer
      第135回日本歯科保存学会秋季学術大会
    • Place of Presentation
      大阪(大阪国際交流センター)
    • Year and Date
      20111020-21
  • [Presentation] 歯肉溝滲出液中のグリコアルブミン測定法の確立2011

    • Author(s)
      板東美香, 稲垣裕司, 木戸淳一, 廣島佑香, 片岡正俊, 村田裕美, 坂東由記子, 二宮雅美, 坂本英次郎, 中島由紀子, 永田俊彦
    • Organizer
      第54回日本歯周病学会春季学術大会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Year and Date
      20110527-28
  • [Presentation] 歯肉溝滲出液中のYKL-40の分析2011

    • Author(s)
      坂東由記子, 木戸淳一, 廣島佑香, 板東美香, 稲垣裕司, 村田裕美, 四釜洋介, 船木真理, 永田俊彦
    • Organizer
      第54回日本歯周病学会秋季学術大会
    • Place of Presentation
      下関(海峡メッセ下関)
    • Year and Date
      2011-09-24

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Published: 2013-07-31  

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