2011 Fiscal Year Final Research Report
Parasites-adaptation to vector environments in Plasmodium
| Project/Area Number |
22890128
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Ehime University |
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Principal Investigator |
SHINZAWA Naoaki 愛媛大学, 大学院・医学系研究科, 助教 (10583015)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ハマダラカ / マラリア / 自然免疫 / 分子生物学 |
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| Research Abstract |
Blood-feeding assay of rodent malaria parasites with Anopheles stephensi revealed that a wild-type variant, named as PbR, represented refractoriness for P. berghei, but not for P. yoelii. In parasites stage-specific analysis, we found incomplete differentiation to ookinetes in the PbR midgut in P. berghei infection. Our results suggest that midgut-parasites interaction control parasite-differentiation which is the key factor of adaptation mechanisms evolving specie-specifically.
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