2011 Fiscal Year Final Research Report
Effect of the novel virulence factor Tap in virulence of Porphyromonas gingivalis
| Project/Area Number |
22890142
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 歯学 / 細菌 / 歯周病 / Porphyromonas gingivalis |
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| Research Abstract |
Porphyromonas gingivalis is one of the most etiologically important microorganisms in periodontal disease. We reported in a previous study that a tprA mutant was clearly less virulent in the mouse subcutaneous abscess model and that tprA is involved in virulence of P. gingivalis. Although TprA, TapA, TapB and TapC proteins seem to be cooperatively involved in P. gingivalis virulence, functions of these proteins are not certain. Then we investigated the role of TapA, TapB and TapC in P. gingivalis virulence through analysis of functions and gene expressions.
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