2011 Fiscal Year Final Research Report
The Post-translational modifications of HIV proteins
| Project/Area Number |
22890149
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Yokohama City University |
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Principal Investigator |
MIYAKAWA Kei 横浜市立大学, 医学研究科, 客員研究員 (20580046)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 翻訳後修飾 |
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| Research Abstract |
Human cells defend against retroviral infection through the actions of intrinsic restriction factors such as BST2.BST2 restricts the release of progeny virions from infected cells, while the HIV-1 protein Vpu antagonizes this restriction. Although the activity of Vpu is regulated by the phosphorylation, the precise regulatory mechanism for the phosphorylation-dependent Vpu function remains elusive. We here report that SCYL2 facilitates BST2-dependent restriction of viral release by inducing dephosphorylation of Vpu. The molecular machinery regulating the post-translational modifications of HIV proteins may be an alternative therapeutic target for HIV/AIDS.
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Research Products
(7 results)
