2011 Fiscal Year Final Research Report
The functional role of angiotensin receptor-binding molecule in chronic kidney disease and metabolic disorders.
| Project/Area Number |
22890150
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Research Collaborator |
TAMURA Kouichi 横浜市立大学, 医学部, 准教授 (40285143)
UMEMURA Satoshi 横浜市立大学, 医学研究科, 教授 (00128589)
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| Project Period (FY) |
2010 – 2011
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| Keywords | レニンアンジオテンシン系 / 受容体 / 慢性腎臓病 / 高血圧 |
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| Research Abstract |
The AT1 receptor(AT1R)-associated protein(ATRAP) is a molecule specifically interacting with the carboxyl-terminal domain of AT1R. In the present study, we demonstrated that a kidney-specific regulatory balancing of ATRAP and AT1R expression may be involved in the modulation of AT1R signaling at local tissue sites and also in the pathophysiology of hypertension and its associated renal injury. Furthermore, we showed that AT1R blockade, ARB, attenuated hypertension and renal injury concomitant with the sustained recovery of renal ATRAP expression. These results suggest that ATRAP can be a novel therapeutic target in chronic kidney disease.
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[Journal Article] Prepubertal angiotensin blockade exerts long-term therapeutic effect through sustained ATRAP activation in salt-sensitive hypertensive rats2011
Author(s)
Dejima T, Tamura K, Wakui H, Maeda A, Ohsawa M, Kanaoka T, Haku S, Kengo A, Masuda SI, Shigenaga AI, Azuma K, Matsuda M, Yabana M, Hirose T, Uchino K, Kimura K, Nagashima Y, Umemura S.
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Journal Title
J Hypertens
Volume: 29
Pages: 1919-29
Peer Reviewed
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[Journal Article] Effects of multiple factorial intervention on ambulatory BP profile and renal function in hypertensive type 2 diabetic patients with overt nephropathy-a pilot study2011
Author(s)
Kanaoka T, Tamura K, Moriya T, Tanaka K, Konno Y, Kondoh S, Toyoda M, Umezono T, Fujikawa T, Ohsawa M, Dejima T, Maeda A, Wakui H, Haku S, Yanagi M, Mitsuhashi H, Ozawa M, Okano Y, Ogana N, Yamakawa T, Mizushima S, Suzuki D, Umemura S.
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Journal Title
Clin Exp Hypertens
Volume: 33
Pages: 255-263
Peer Reviewed
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[Journal Article] Involvement of Runx3 in the basal transcriptional activation of the mouse angiotensin II type 1 receptor-associated protein gene2011
Author(s)
Matsuda M, Tamura K, Wakui H, Dejima T, Maeda A, Ohsawa M, Kanaoka T, Haku S, Azushima K, Yamasaki H, Saito D, Hirose T, Maeshima Y, Nagashima Y, Umemura S.
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Journal Title
Physiol Genomics
Volume: 43
Pages: 884-94
Peer Reviewed
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[Journal Article] Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice2010
Author(s)
Wakui H, Tamura K, Matsuda M, Bai Y, Dejima T, Shigenaga A, Masuda S, Azuma K, Maeda A, Hirose T, Ishigami T, Toya Y, Yabana M, Minamisawa S, Umemura S.
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Journal Title
Am J Physiol Renal Physiol
Volume: 299
Pages: 991-1003
Peer Reviewed
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[Journal Article] Expression of angiotensin II type 1 receptor-interacting molecule in normal human kidney and IgA nephropathy2010
Author(s)
Masuda S, Tamura K, Wakui H, Maeda A, Dejima T, Hirose T, Toyoda M, Azuma K, Ohsawa M, Kanaoka T, Yanagi M, Yoshida S, Mitsuhashi H, Matsuda M, Ishigami T, Toya Y, Suzuki D, Nagashima Y, Umemura S.
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Journal Title
Am J Physiol Renal Physiol
Volume: 299
Pages: 720-31
Peer Reviewed
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