2011 Fiscal Year Final Research Report
Molecular mechanism of proteolytic cleavage of Reelin
| Project/Area Number |
22890155
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
TAKAO Kohno 名古屋市立大学, 大学院・薬学研究科, 助教 (70581742)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経細胞 / 脳 / リーリン / プロテアーゼ |
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| Research Abstract |
Reelin is a large protein that is essential for brain development. Reelin is proteolytically cleaved at specific sites. In this study, we aimed to clarify the molecular mechanism of proteolytic cleavage of Reelin. We found following points.(1) Reelin does not have the proteolytic activity.(2) A disintegrin and metalloproteinase with thrombospondin motifs 4(ADAMTS-4) can cleave Reelin in an isoform-dependent manner.(3) Reelin with an intact CTR binds to a transmembrane protein that is different from the well-known Reelin receptors.
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