2011 Fiscal Year Final Research Report
Advances in the understanding of mechanisms of intracellular signaling by thrombomodulin in the hypersensitivity state
| Project/Area Number |
22890159
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 痛覚過敏 / トロンボモジュリン / 細胞内シグナリング |
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| Research Abstract |
We found out an increase in HMGB-1 protein expression in the primary sensory neurons after spinal nerve ligation(SNL). We examined the thresholds to painful stimuli after thrombomodulin, which could neutralize the efficacy of HMGB-1, was injected into the sciatic nerve of SNL model rats. We found out that thrombomodulin alleviated pain hypersensitivity. Although thrombomodulin, which was injected to SNL model rats, could alleviate the thresholds both heat and mechanical stimuli, we failed to figure out mechanisms of intracellular signaling. Moreover we found out the dose dependency of the efficacy of thrombomodulin to the pain hypersensitivity.
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