2011 Fiscal Year Final Research Report
Effects of BMP2 and FGF2 on the odontoblast differentiation and the induction methods of expression of cell function for the regeneration of dental pulp.
| Project/Area Number |
22890167
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
WASHIO Ayako 九州歯科大学, 歯学部歯学科, 助教 (10582786)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 象牙質・歯髄複合体 / 再生医療 |
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| Research Abstract |
We examined the effects of Bone Morphogenic Protein-2(BMP-2) and Fibroblast Growth Factor-2(FGF-2), on the odontoblast differentiation of KN-3 cells, a cell line that we established from dental pulp. Our results indicate that BMP-2 and FGF-2 play critical roles in induction of the odontoblast properties of KN-3 cells via activation of Smad and ERK signaling pathways, respectively. We could have useful knowledge about the establishment of wound healing and local regeneration of dentin-pulp complex.
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