2011 Fiscal Year Final Research Report

Novel imaging analytical method for measuring the stimulus-induced activity of the cranial nerves

Research Project

Project/Area Number	22890168
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Prosthetic dentistry
Research Institution	Health Sciences University of Hokkaido
Principal Investigator	KONO Mai 北海道医療大学, 歯学部, 助教 (90586926)
Project Period (FY)	2010 – 2011
Keywords	脳神経活動 / 咀嚼機能 / MRI / MEMRI
Research Abstract	In this study, we examined the hypothesis that manganese-enhaced MRI(MEMRI) can detect the effect of physiological and unphysiologocal occlusal force on the behavior of magnesium ion in the brain. As a first step, we investigated the time-dependent change in brain distribution of injected magnesium ion. The high signal intensity was observed in lateral cerebral ventricle and hippocampus at 1 hour post-injection. The signal of magnesium ion was consistently until 6 hours after administration. Next, rats forget for food immediately after administration to examine the effect of chewing on the signal intensity. However, MEMRI can not detect the change in the signal intensity due to the restricted voluntary chewing. It seemed that the toxic side-effect of magnesium reduced food intake and spontaneous activity.

(1 results)