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2011 Fiscal Year Final Research Report

Social brain function deficits and psychosis in schizophrenia and Asperger's disorder

Research Project

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Project/Area Number 22890179
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionShowa University

Principal Investigator

HASHIMOTO Ryuichiro  昭和大学, 医学部, 講師 (00585838)

Project Period (FY) 2010 – 2011
Keywords統合失調症 / 自閉症スペクトラム障害 / 社会機能 / 幻聴 / 言語 / 選択的注意 / 流動性知能 / fMRI
Research Abstract

Using functional magnetic resonance imaging(fMRI), I conducted a series of experiments that aimed to identify deficient neural cognitive mechanisms that underlie social and communicative problems in schizophrenia and autism spectrum disorders(ASD), including Asperger's disorder. In experiments for schizophrenia, we identified multiple levels of functional abnormalities in the auditory language system that underlie auditory hallucinations. In experiments for ASD, we revealed significant association between deficiency of selective attention and the severity of ASD symptoms. These findings help to identify critical neural abnormalities responsible for schizophrenia and ASD, each of which is characterized by social and communicative deficits.

  • Research Products

    (10 results)

All 2012 2011 Other

All Journal Article (1 results) Presentation (8 results) Book (1 results)

  • [Journal Article] An fMRI Study of Reduced Perceptual Load-dependent Modulation of Task-irrelevant Activity in Adults with Autism Spectrum Conditions2012

    • Author(s)
      Ohta, H., Yamada, T., Watanabe, H., Kanai, C., Tanaka, E., Ohno, T., Takayama, Y., Iwanami, A., Kato, N., Hashimoto, R.
    • Journal Title

      Neuroimage

      Volume: 61(4) Pages: 1176-1187

  • [Presentation] The neural basis of selective attention deficits in autism spectrum disorder2011

    • Author(s)
      Ohta H., Hashimoto R., Yamada T., Tani M., Watanabe H., Kanai C., Ohno T., Takayama Y., Iwanami A., & Kato N.
    • Organizer
      Society for Neuroscience 2011
    • Place of Presentation
      ワシントンDC,アメリカ
    • Year and Date
      20111100
  • [Presentation] Neural basis of fluid intelligence in autism spectrum disorder2011

    • Author(s)
      Yamada T., Hashimoto R., Ohta H., Watanabe H., Yamada T., Ohno T., Takayama Y., Tani M., Iwanami A., & Kato N.
    • Organizer
      Society for Neuroscience 2011
    • Place of Presentation
      ワシントンDC,アメリカ
    • Year and Date
      20111100
  • [Presentation] An fMRI Study of Selective Attention Deficits in Adult Autism Spectrum Disorder2011

    • Author(s)
      Hashimoto, R., Ohta, H., Yamada T., Mimura M., Iwanami A., Kato, N.
    • Organizer
      The 17th Annual Meeting of the organization on Human Brain Mapping
    • Place of Presentation
      ケベック,カナダ
    • Year and Date
      20110600
  • [Presentation] 自閉症スペクトラム障害における選択的注意の障害の脳基盤2011

    • Author(s)
      太田晴久、橋本龍一郎、山田貴志、谷将之、金井智恵子、大野泰正、高山裕子、長谷川澄、岩波明、加藤進晶
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      20110500
  • [Presentation] 幻聴に対する治療効果を反映する脳機能指標の計測:機能的MRIを用いた検討2011

    • Author(s)
      長谷川澄・三村将・谷将之・吉村直紀・大野泰正・高山裕子・山田貴志・太田晴久・加藤進晶・橋本龍一郎
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      20110500
  • [Presentation] 自閉症スペクトラム障害における流動性知能課題施行時の脳活動: fMRIによる検討2011

    • Author(s)
      山田貴志、橋本龍一郎、太田晴久、金井智恵子、谷将之、渡部洋実、大野泰正、高山裕子、岩波明、加藤進晶
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      20110500
  • [Presentation] The neural basis of selective attention deficits in autism spectrum disorder2011

    • Author(s)
      Ota H., Hashimoto R., Yamada T., Tani M., Takayama Y., Ohno T., Iwanami A., & Kato N.
    • Organizer
      The 10th World Congress of Biological Psychiatry
    • Place of Presentation
      プラハ,チェコ共和国
    • Year and Date
      20110500
  • [Presentation] Neural basis of fluid intelligence in autism spectrum disorder2011

    • Author(s)
      Yamada T., Hashimoto R., Ohta H., Watanabe H., Tani M., Kanai C., Mimura O., Iwanami A., & Kato N.
    • Organizer
      The 10th World Congress of Biological Psychiatry
    • Place of Presentation
      プラハ,チェコ共和国
    • Year and Date
      20110500
  • [Book] 抗精神病薬の脳構造、脳機能に及ぼす影響,向精神薬のリスク・ベネフィット(「専門医のための精神科臨床リュミエール25」)

    • Author(s)
      夏堀龍暢・八幡憲明・井上秀之・橋本龍一郎・笠井清登
    • Total Pages
      90-101
    • Publisher
      中山書店

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Published: 2013-07-31  

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