2011 Fiscal Year Final Research Report
Functions of Rac1 during bone and cartilage formation
| Project/Area Number |
22890180
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
SUZUKI Dai 昭和大学, 歯学部, 助教 (00585797)
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| Research Collaborator |
KAMIJO Ryutaro 昭和大学, 歯学部, 教授 (70233939)
YAMADA Atsushi 昭和大学, 歯学部, 講師 (50407558)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 遺伝子 / 発生・分化 / 細胞・組織 / 骨・軟骨 |
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| Research Abstract |
Rac1, a member of the Rho subfamily of small GTPases, is known to be a regulator of multiple cellular functions, including cytoskeletal organization, cell migration, proliferation, and apoptosis. To investigate the physiological function of Rac1 during bone and cartilage formation, we generated tissue-specific inactivated Rac1(Rac1fl/fl ; Prx1-Cre) mice. Rac1 conditional knockout mice demonstrated short limbs and incomplete fusions of the cranium. Our results infer that short limb was caused by abnormal endochondral ossification and incomplete fusion of the cranium was due to enhanced mineralization.
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[Presentation] Essential role of Cdc42 in chondrogenesis and interdigital programmed cell death during limb development2011
Author(s)
Ryo Aizawa, Atsushi Yamada, Dai Suzuki, Hidetoshi Kassai, Takeshi Harada, Masayuki Tsukasaki, Gou Yamamoto, Tadahiro Iimura, Akira Yamaguchi, Kazuki Nakao, Matsuo Yamamoto, Atsu Aiba, Ryutaro Kamijo
Organizer
The 33th Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
San Diego, California, USA
Year and Date
20110916-20
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[Presentation] TNF-α Suppresses POEM Expression in Osteoblasts2011
Author(s)
Tsukasaki M, Yamada A, Miyazono A, Suzuki D, Yoshimura K, Aizawa R, Miyamoto Y, Takami M, Suzawa T, Morimura N, Aruga J, Yamamoto M, Kamijo R
Organizer
89th General Session & Exhibition of the International Associate for Dental Research(IADR)
Place of Presentation
San Diego, California, USA
Year and Date
20110316-19
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[Presentation] Alx3, a Paired-type Homeodomein Containing Transcription Factor, Regulates Osteoblast Differentiation Induced by BMP-22010
Author(s)
Matsumoto T, Yamada A, Suzuki D, Takami M, Suzawa T, Miyamoto Y, Baba K, Kamijo R
Organizer
The 32nd Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Toronto, Canada
Year and Date
20101015-19
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