2011 Fiscal Year Final Research Report

Study on the novel metabolic pathway of phosphatidylinositol to produce endogenous cannabinoid.

Research Project

Project/Area Number	22890193
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Biological pharmacy
Research Institution	Teikyo University
Principal Investigator	HAYASHI Yasuhiro 帝京大学, 薬学部, 助教 (70582857)
Project Period (FY)	2010 – 2011
Keywords	リン脂質
Research Abstract	GPR55 is a seven-transmembrane G-protein-cpupled receptor that has been proposed as a novel type of cannabinoid receptor. Previously, we identified lysophosphatidylinositol(LPI), in particular 2-arachidonoyl-LPI, as an agonist for GPR55.In the present study, we tried to identify PI-PLA1 and PI-PLA2 to clear the novel metabolic pathway of PI. To clear the novel function of phospholipid-metabolic enzymes, we examined the efficiency of Cell-Cell fusion of overexpressed or knockdown cells. The cell-cell fusion activity were increased in these cells. These results suggest that phospholipid-metabolic enzymes are involeved in cell-cell fusion.

(4 results)