2011 Fiscal Year Final Research Report
Does the podocyte damage is non-invertible? Inquest therapeutic modality for the damage.
| Project/Area Number |
22890196
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo (2011)
Teikyo University (2010) |
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Principal Investigator |
WATANABE Sumiyo 東京大学, 大学院・医学系研究科, 特任研究員 (30422314)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 慢性腎不全 / 腎足細胞 / p130-Cas / 遺伝子治療 / ナノキャリア |
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| Research Abstract |
Brief overview : This theme is focused on the point that'' podocyte has the same signal transduction as skeletal muscle to the extent of existing actin signal pathway''. The skeletal muscle tissue and renal podocyte have a common pathway, it means that podocyte damage can be healed as muscle skeletal damage though the accepted notion of nowadays is that'' podocyte damage is never recovered''. We made podocyte damage mice. We will try to cure their renal function by'' genetic manipulation nanocarrier'' which have been developed by ourselves.
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