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2011 Fiscal Year Final Research Report

Role of Sulf in Cartilage Metabolism

Research Project

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Project/Area Number 22890217
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionOsaka Medical College

Principal Investigator

OTSUKI Shuhei  大阪医科大学, 医学部, 助教 (20589840)

Project Period (FY) 2010 – 2011
KeywordsSulf / ヘパラン硫酸 / 加齢 / 変形性関節症 / 軟骨
Research Abstract

Abnormally increased mechanical load due to varus deformity is associated with cartilage degradation in the medial condyle. Interestingly, the tissue damage caused by mechanical stress activates a cellular response that leads to proliferation of STRO-1positive progenitor cells and cluster formation. On the other hand, thick non-degenerated cartilage in the lateral compartment that experiences reduced load due to varus deformity shows low-density single chondrocytes that appear to have reduced proliferative and biosynthetic activity. Appropriate mechanical stress appears critical for maintaining cartilage homeostasis and early restoration of normal mechanical load in both compartments of the knee may prevent cell and tissue damage.

  • Research Products

    (1 results)

All 2012

All Presentation (1 results)

  • [Presentation] Cartilage Thickness and Chondrocyte Density in Human Osteoarthritic Knee Joints2012

    • Author(s)
      Otsuki S., et al
    • Place of Presentation
      Barcelona Spain
    • Year and Date
      2012-04-25

URL: 

Published: 2013-07-31  

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