2011 Fiscal Year Final Research Report
The role of the infiltration of inflammatory cells through plasmin activation in the development of NASH-induced fibrosis
| Project/Area Number |
22890221
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | NASH / プラスミン / マクロファージ |
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| Research Abstract |
Non alcoholic steatohepatitis(NASH), which is occurred on the basis of metabolic disorders such as metabolic syndrome, can progress to the fibrotic steatohepatitis, cirrhosis and hepatocalcinoma. Therefore, it is very important to clarify the mechanisms of the pathogenesis of NASH and establish the therapeutic strategy for this pathological state. In the present study, the role of plasminogen/plasmin, which plays a central role of fibrinolysis, in the development of NASH was examined using plasminogen-deficient mice or plasmin inhibitor. Our study demonstrated that plasmin contributes to the development of NASH presumably through promoting the macrophage infiltration and its activation, and also showed the possibility of plasmin inhibitor as therapeutic agent for NASH.
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[Journal Article] Urokinase-type plasminogen activator and plasminogen mediate activation of macrophage phagocytosis during liver repair in vivo2012
Author(s)
Kawao N, Nagai N, Tamura Y, Horiuchi Y, Okumoto K, Okada K, Suzuki Y, Umemura K, Yano M, Ueshima S, Kaji H, Matsuo O
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Journal Title
Thromb Haemost
Volume: 107(4)
Pages: 749-59
Peer Reviewed
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