2011 Fiscal Year Final Research Report
Screening and elucidation of an allergic exacerbation-barrier disruption action substance in environment and food
| Project/Area Number |
22890222
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 腸管バリア / 環境汚染物質 |
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| Research Abstract |
Epithelial cells surround mammalian organs and tissues and epithelial cell sheets constitute the principal barrier to cellular uptake and transport. The tight junction(TJ) plays a pivotal role as both a barrier to restrict various substances, such as pathogens, toxins, and allergens. In this study, we screened the chemical substances to disruption of barrier function and disturbance of immune system in environment and food. It was observed that various environmental pollutants were decreased barrier function of TJ. Furthermore, we observed that treatment of mice with dioxins and antigen results in significant elevation antigen-specific immunoglobulin production in a dose-dependent manner. There results suggest the chemical substance in environment and food dysregulates the barrier function and immune system.
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Research Products
(4 results)
