2011 Fiscal Year Final Research Report
The study on epithelial cells-mediated development of allergic diseases
Project/Area Number |
22890224
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Hyogo Medical University |
Principal Investigator |
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Research Collaborator |
YOSHIMOTO Tomohiro 兵庫医科大学, 医学部, 教授 (60241171)
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Project Period (FY) |
2010 – 2011
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Keywords | アレルギー / ぜんそく |
Research Abstract |
IL-33 is a newly identified IL-1 family cytokine, which stimulates basophile, mast cell, dendritic cell or T cell to augment Th2 response and exacerbate allergic diseases. Recent studies have revealed not only cleaved, so called"mature-form", but also full length, so called"pre-form", IL-33 has its biological activity suggesting the importance of IL-33 up-regulation itself in the initiation or exacerbation of allergic diseases. However, the mechanisms for IL-33 induction are yet to be fully uncovered. Here, we studied the regulatory mechanisms of IL-33 protein and mRNA expression in Ragweed pollen induced allergic rhinitis and asthma mouse model. Further more, to gain insight into the precise regulatory mechanisms for IL-33 mRNA expression in the epithelial cells, we investigated Ragweed pollen and PMA and ionomycin induced IL-33 mRNA expression in human bronchial epithelial cell line, BEAS-2B.
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Research Products
(7 results)
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[Journal Article] A critical role of IL-33 in experimental allergic rhinitis2012
Author(s)
Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Imoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, Nakanishi K, Yoshimoto T.
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Journal Title
J. Allergy Clin. Immunol
Volume: (in press)
Peer Reviewed
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[Journal Article] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Taki Y, Futatsugi-Yumikura S, Tsutsui H, Ishii KJ, Yoshimoto T, Akira S, Nakanishi K.
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Journal Title
Proc. Natl. Acad. Sci. U. S. A
Volume: 109
Pages: 3451-3456
Peer Reviewed
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[Journal Article] The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection2010
Author(s)
Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K and Akira S.
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Journal Title
Nat. Immunol
Volume: 11
Pages: 926-44
Peer Reviewed
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