2011 Fiscal Year Final Research Report
Protection of photoreceptors by inhibiting Rac1 and NADPH oxidase in an animal model of retinitis pigmentosa
| Project/Area Number |
22890230
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 網膜色素変性 / RCSラット / NADPHオキシダーゼ / 視細胞 / アポトーシス / 神経保護 / 光傷害 / Rac1 |
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| Research Abstract |
The RCS rat is a widely studied animal model of retinitis pigmentosa. In this study,4-week-old RCS rats were injected intraperitoneally either with NADPH oxidase inhibitor (apocynin, 50mg/kg) or vehicle only. Eyes from 8-week and 12-week-old RCS rats were used for histologic evaluation. Photoreceptor cell number was evaluated by measuring outer nuclear layer thickness on retinal sections. However, there was no statistical differencein outer nuclear layer thickness between apocynin-injected and sham-injected RCS rats.
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