2011 Fiscal Year Final Research Report
Treating neonatal hypoxic-ischemic encephal opathy with substances that exist in the placenta and cord blood
| Project/Area Number |
22890254
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
TSUJI Masahiro 独立行政法人国立循環器病研究センター, 再生医療部, 室長 (80579467)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 新生児医学 |
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| Research Abstract |
Progesterone and its metabolite, allopregnanolone, are neurosteroids that are present at high concentrations in fetal brains. Allopregnanolone is a potent positive modulator ofγ-aminobutyric acid A(GABA_A) receptor function. We examined the effect of exogenous administration of these steroids on hypoxic-ischemic encephalopathy in immature rats. Both progesterone and allopregnanolone significantly exacerbated brain injury in P7(postnatal day 7) and P14 rats, but not in P21 rats. Co-administration of the GABA receptor antagonist, bicuculline, partially A mitigated the exacerbating effect of allopregnanolone. This is in line with the notion that GABA is excitatory for immature neurons, while it is inhibitory for mature neurons.
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