Role of mitochondrial respiratory function of the epicardial addipose tissue for atrial fibrillation

2024 Fiscal Year Final Research Report

• Project/Area Number: 22K08197
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Hokkaido University
• Principal Investigator: Watanabe Masaya 北海道大学, 医学研究院, 客員研究員 (40632047)
• Co-Investigator(Kenkyū-buntansha): 畑中 豊 北海道大学, 大学病院, 特任准教授 (30589924) ; 新宮 康栄 北海道大学, 医学研究院, 講師 (30617064) ; 横田 卓 北海道大学, 大学病院, 特任講師 (90374321)
• Project Period (FY): 2022-04-01 – 2025-03-31
• Keywords: 心外膜脂肪 / 心房細動 / ミトコンドリア呼吸能

Outline of Final Research Achievements

Epicardial adipose tissue samples and clinical data were collected from 53 patients. As initially hypothesized, no significant differences were observed in atrial remodeling markers or postoperative atrial fibrillation incidence between groups divided by the median of mitochondrial oxygen consumption. Adipocytokine secretion from epicardial adipose tissue was measured using immunoassays, and correlations with mitochondrial respiration per tissue weight were evaluated. Mitochondrial respiration showed a positive correlation with MCP1 and adiponectin levels. Conversely, a strong negative correlation was observed between mitochondrial respiration and adipocyte cross-sectional area, suggesting an association between mitochondrial function and adipocyte density within the tissue.

Free Research Field

循環器病学

Academic Significance and Societal Importance of the Research Achievements

心臓周囲脂肪におけるミトコンドリア呼吸能が脂肪組織の形態変化や分泌機能にどのように影響するかについて、新たな知見を得ることができた。研究成果により、心房細動基質と心外膜脂肪組織との関連についての知見を加えることができた。
また、術後心房細動の発生率やその発生に関わる患者因子についても知見を加えることができた。