2024 Fiscal Year Final Research Report
Development of an innovative PDT by combining click reaction technology with axially linked sugar-linked porphyrin complexes
| Project/Area Number |
22K08806
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
横谷 篤至 宮崎大学, 工学部, 教授 (00183989)
徐 岩 宮崎大学, 医学部, 教授 (40506763)
菱川 善隆 宮崎大学, 医学部, 教授 (60304276)
松本 仁 宮崎大学, 工学部, 准教授 (90363572)
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| Project Period (FY) |
2022-04-01 – 2025-03-31
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| Keywords | PDT / PDD / 胆管癌 / グルコーストランスポーター / P型軸配子型錯体 / 殺細胞効果 / 光吸収率測定 / LED |
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| Outline of Final Research Achievements |
The study evaluated the photophysical properties of a hybrid P-porphyrin complex, including fluorescence quantum yield, lifetime, and singlet oxygen generation in organic and aqueous media, compared with sugar-linked BODIPY. The hybrid complex was tested for phototoxicity in NOZ and HepG2 cancer cells under 610 nm LED light, with GLUT inhibitors used to assess cell recognition. Despite synthesizing BODIPY derivative 1 and sugar-linked P-porphyrin complex 2 via click chemistry, the final hybrid compound was not completed. Cancer cell evaluation and in vivo studies were delayed, and tumor-targeting conjugation remains unfinished.
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| Free Research Field |
消化器外科
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| Academic Significance and Societal Importance of the Research Achievements |
PDTとPDDを同時に施行できるプローブを作成できなかったが、現在これらを2剤conjugateして施行しうる道筋を立てている。これまでの方法論を基礎に次回の研究成果につなげていき、臨床における難治性胆管がんの局所治療へのtranslationを達成したい
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