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2023 Fiscal Year Research-status Report

データコラボレーション解析による分散協調特徴量選択手法の研究

Research Project

Project/Area Number 22K12144
Research InstitutionUniversity of Tsukuba

Principal Investigator

叶 秀彩  筑波大学, システム情報系, 准教授 (60814001)

Project Period (FY) 2022-04-01 – 2026-03-31
Keywordsfeature learning
Outline of Annual Research Achievements

This year, we focus on the research on feature learning-based methods and their application in bioinformatics. To address the challenges of limited samples and data imbalance, we present a novel framework for feature learning to analyze complex data structures, which are applied to predict antibiotic activity and enhance the efficiency of antibiotic discovery. In order to effectively learn the complex data, we utilize contrastive learning to extract the important features from complex structures. By integrating data augmentation and a pre-trained RoBERTa model, our method is able to accurately predict the hEFG blocker.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

In addressing the challenges posed by limited samples and imbalances within them, we introduce innovative methods to enhance feature learning and analyze complex data structures. Our approaches employ contrastive learning to effectively capture critical features from complex datasets, and integrates data augmentation alongside a pre-trained RoBERTa model to predict hEFG blockers with high precision, thus advancing the field of antibiotic discovery.

Strategy for Future Research Activity

In the next step, we will address with data that is distributed in different locations. We're going to propose methods that learn from the data together without compromising privacy. We'll use effective techniques, including federated learning, to learn important features from the data. We're also planning to apply these methods to data that comes from multiple perspectives to improve how we combine and use this kind of data.

Causes of Carryover

This year, due to the high number of classes scheduled for the fall semester, I am unable to participate in some international conferences.
Nest year, I plan to join the international conference and collect the information about the latest research on feature learning and distributed data analysis.

  • Research Products

    (7 results)

All 2024 2023

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) (of which Int'l Joint Research: 3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] FIAMol-AB: A feature fusion and attention-based deep learning method for enhanced antibiotic discovery2024

    • Author(s)
      He Shida、Ye Xiucai、Dou Lijun、Sakurai Tetsuya
    • Journal Title

      Computers in Biology and Medicine

      Volume: 168 Pages: 107762~107762

    • DOI

      10.1016/j.compbiomed.2023.107762

    • Peer Reviewed
  • [Journal Article] CLOP-hERG: The Contrastive Learning Optimized Pre-Trained Model for Representation Learning in Predicting Drug-Induced hERG Channel Blockers2024

    • Author(s)
      He Shida、Ye Xiucai、Sakurai Tetsuya
    • Journal Title

      Medinformatics

      Volume: - Pages: 1~9

    • DOI

      10.47852/bonviewMEDIN42022049

    • Peer Reviewed
  • [Journal Article] Multi-omics clustering for cancer subtyping based on latent subspace learning2023

    • Author(s)
      Ye Xiucai、Shang Yifan、Shi Tianyi、Zhang Weihang、Sakurai Tetsuya
    • Journal Title

      Computers in Biology and Medicine

      Volume: 164 Pages: 107223~107223

    • DOI

      10.1016/j.compbiomed.2023.107223

    • Peer Reviewed
  • [Presentation] Multi-omics clustering based on interpretable and discriminative features for cancer subtyping2023

    • Author(s)
      Tianyi Shi, Xiucai Ye, Tetsuya Sakurai
    • Organizer
      IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
    • Int'l Joint Research
  • [Presentation] Multi-view Network Embedding with Structure and Semantic Contrastive Learning2023

    • Author(s)
      Yifan Shang, Xiucai Ye, Tetsuya Sakurai
    • Organizer
      IEEE International Conference on Multimedia and Expo (ICME)
    • Int'l Joint Research
  • [Presentation] Common and Unique Features Learning in Multi-view Network Embedding2023

    • Author(s)
      Yifan Shang, Xiucai Ye, Tetsuya Sakurai
    • Organizer
      International Joint Conference on Neural Networks (IJCNN)
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 特徴量選択支援プログラム及び特徴量選択支援方法2023

    • Inventor(s)
      今倉暁, 叶 秀彩, 櫻井鉄也
    • Industrial Property Rights Holder
      今倉暁, 叶 秀彩, 櫻井鉄也
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      7302851

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Published: 2024-12-25  

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