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2023 Fiscal Year Research-status Report

Development of rapid and sensitive bioassay methods to contribute to actinide internal exposure medical response

Research Project

Project/Area Number 22K12384
Research InstitutionNational Institutes for Quantum Science and Technology

Principal Investigator

楊 国勝  国立研究開発法人量子科学技術研究開発機構, 放射線医学研究所 計測・線量評価部, 主任研究員 (10801227)

Co-Investigator(Kenkyū-buntansha) 金 ウンジュ  国立研究開発法人量子科学技術研究開発機構, 放射線医学研究所 計測・線量評価部, 主幹研究員 (10370876)
鄭 建  国立研究開発法人量子科学技術研究開発機構, 放射線医学研究所 計測・線量評価部, 上席研究員 (30370878)
Project Period (FY) 2022-04-01 – 2025-03-31
KeywordsAtctinides / Bioassay / Radiation emergency / PROCORAD intercomparison / ICP-MS/MS / Alpha spectrometry
Outline of Annual Research Achievements

The developed urinary bioassay methods in last year were applied to measured U, Pu, and Am isotopes by ICP-MS/MS in the urinary samples collected during the Oarai Pu/Am exposure accident. The data of ICP-MS/MS were comparable with that of alpha spectrometry. In addition, the developed urinary and fecal bioassay methods were also applied to participate in the annual intercomparison organized by PROCORAD, France. Based on the performance criteria including Z-score, bias, and En value, our lab qualified as TOP LABO for these comparisons: Actinides in urine with DTPA (2023), Actinides in urine (2023), and Uranium in fecal ashes (2023). These indicated the developed urinary and fecal bioassay methods are able to measure actinides rapidly in urinary and fecal samples.

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

This year, we focused on the application of the developed urinary and fecal bioassay methods to measure actinides in contaminated urinary samples and participate in interlaboratory comparison for method validation. The development of bioassay method in blood to measure actinides was somewhat delayed.

Strategy for Future Research Activity

The development of fecal bioassay method to measure actinides by ICP-MS/MS are expected to be published as papers. The development of bioassay method for the measurement of actinides in blood sample will be performed in this year. The remaining urinary samples collected during the Oarai Pu/Am exposure accident will be measured by the developed methods with ICP-MS/MS, to compare with that of alpha spectrometry. In addition, the developed methods could also provide additional information, such as the 240Pu/239Pu atom ratio, uranium isotopes.

Causes of Carryover

For the method development to measure actinides in blood samples, blood samples, required reagents and materials (e.g. acid to decompose organic matters in blood, resin cartridge for purification of actinides in blood) for experiment are to be purchased.
In order communicate with other researchers and obtain the latest information, I also want to use the budget to participate in domestic and international conferences.

  • Research Products

    (11 results)

All 2023

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results)

  • [Journal Article] 90Sr bioassay in small-volume urine by ICP-MS/MS with CO2 as the reaction gas2023

    • Author(s)
      Yang Guosheng、Tazoe Hirofumi、Kim Eunjoo、Zheng Jian、Kowatari Munehiko、Kurihara Osamu
    • Journal Title

      Journal of Analytical Atomic Spectrometry

      Volume: 38 Pages: 2562~2570

    • DOI

      10.1039/d3ja00303e

    • Peer Reviewed
  • [Journal Article] Actinide analysis in urine during participating PROCORAD intercomparison2023

    • Author(s)
      Yang Guosheng、Kim Eunjoo、Seno Hatsuho、Kowatari Munehiko、Kurihara Osamu
    • Journal Title

      Journal of Radioanalytical and Nuclear Chemistry

      Volume: - Pages: -

    • DOI

      10.1007/s10967-023-09240-5

    • Peer Reviewed
  • [Presentation] 緊急被ばく医療におけるバイオアッセイ研究と今後の展望2023

    • Author(s)
      Yang, G., Kim, E., Zheng, J., Tazoe, H., Akata, H., Kowatari, M., Kurihara, O.
    • Organizer
      第25回「環境放射能」研究会
    • Invited
  • [Presentation] 量研機構におけるPROCORADバイオアッセイ国際比較 結果(検証値との比較)2023

    • Author(s)
      Yang, G.
    • Organizer
      令和5年度第2回線量評価部会
  • [Presentation] 90Sr bioassay in small-volume urine by ICP-MS/MS with CO2 as the reaction gas in rapid response to radiological emergencies2023

    • Author(s)
      Yang, G., Tazoe, H., Kim, E., Zheng, J., Kowatari, M., Kurihara, O.
    • Organizer
      66th Radiobioassay & Radiochemical Measurements Conference
    • Int'l Joint Research
  • [Presentation] The application of radiometric and mass spectrometric techniques to develop rapid bioassay methods for radiation emergency medicine2023

    • Author(s)
      Yang, G., Kim, E., Zheng, J., Seno, H., Kowatari, M., Kurihara, O.
    • Organizer
      2023 年全国放射化学発展戦略及び学術交流大会(中国)
    • Invited
  • [Presentation] Rapid faecal and urinary bioassay of multiple actinide isotopes by mass and alpha spectrometric techniques2023

    • Author(s)
      Yang, G., Kim, E., Zheng, J., Kowatari, M., Kurihara, O.
    • Organizer
      3rd International Conference on Radioanalytical and Nuclear Chemistry
    • Int'l Joint Research
  • [Presentation] 核燃料物質使用施設におけるバイオアッセイ分析関連放射性廃棄物の 分別・処理状況について2023

    • Author(s)
      妹尾 初穂, 楊 国勝, 岩谷 航平, 椎野 剛成, 宮後 法博, 古渡 意彦, 栗原 治
    • Organizer
      日本放射線安全管理学会 第22回学術大会
  • [Presentation] The development of rapid bioassay methods for radiation emergency medicine2023

    • Author(s)
      Yang, G., Kim, E., Zheng, J., Seno, H., Kowatari, M., Kurihara, O.
    • Organizer
      2023 Annual meeting of Asian Radiation Dosimetry Group (ARADOS)
    • Int'l Joint Research
  • [Presentation] The development of rapid bioassay methods for radiation emergency medicine2023

    • Author(s)
      Yang, G., Kim, E., Zheng, J., Seno, H., Kowatari, M., Kurihara, O.
    • Organizer
      7th International Symposium on the System of Radiological Protection
    • Int'l Joint Research
  • [Presentation] Measurement of actinides and 90Sr in faecal and urinary samples for PROCORAD 20222023

    • Author(s)
      Yang, G., Kim, E., Zheng, J., Seno, H., Tazoe, H., Kowatari, M., Kurihara, O.
    • Organizer
      3rd International Conference on Radioanalytical and Nuclear Chemistry
    • Int'l Joint Research

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Published: 2024-12-25  

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