2023 Fiscal Year Final Research Report
Self-Powered Photoelectrochemical Device for Ultrasensitive Virus Detection using Multi-component Nanoheterostructure
| Project/Area Number |
22K14711
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 34020:Analytical chemistry-related
|
|---|
| Research Institution | National Institute for Materials Science |
|---|
Principal Investigator |
GANGANBOINA Akhilesh Babu 国立研究開発法人物質・材料研究機構, 若手国際研究センター, ICYSリサーチフェロー (90937252)
|
|---|
| Project Period (FY) |
2022-04-01 – 2024-03-31
|
| Keywords | Photoelecrtochemical / Biosensor / Nanomaterial / water oxidation / Encapsulation / Virus / Visible light / Self powered |
|---|
| Outline of Final Research Achievements |
In the absence of therapeutic agents, early virus detection is crucial to prevent outbreaks and control pandemics. We developed a self-powered photoelectrochemical (PEC) biosensor for ultrasensitive detection of hepatitis E virus (HEV), HEV-like particles (HEV-LPs), and SARS-CoV-2 spike protein in complex lysate solutions. This biosensor uses novel electrocatalysts CdSe-Co3O4@TiO2 and Co3O4-CdSe-CdS-Pt, generating a photocurrent response under visible light. Encapsulation within a polymer shell amplifies the detection signal. Enhanced photocurrent response is due to CdSe quantum dots' sensitization and strong light absorption, coupled with Co3O4's stability. The biosensor shows a linear relationship between photocurrent output and virus concentration (10 fg/mL to 10 ng/mL), offering high sensitivity, specificity, and stability. This development shows significant potential for creating affordable, portable biosensing devices
|
| Free Research Field |
Nanomaterials and Bio Analytical chemistry
|
| Academic Significance and Societal Importance of the Research Achievements |
この研究は、ウイルス検出技術の大きな進歩を表しています。新しい光電気触媒を開発することで、感度と光電流応答が大幅に向上しました。このデバイスは、10 fg/mLという非常に低い濃度のE型肝炎ウイルスとSARS-CoV-2スパイクタンパク質を検出できます。手頃な価格で持ち運び可能な当社のバイオセンシングデバイスは、現場での迅速なウイルス検出を提供します。これは、特にリソースが限られた環境でのタイムリーな公衆衛生対応に不可欠です。この技術は、感染率を下げ、医療システムへの負担を軽減し、最終的には人命を救うのに役立ち、世界の健康に大きなプラスの影響をもたらします。
|
