2023 Fiscal Year Research-status Report
Control morphology and drug release of nanodrugs through templated crystallization of poorly water-soluble compounds
| Project/Area Number |
22K14742
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2026-03-31
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| Keywords | cancer therapy / noble metal / prodrug / templated crystallize / nanomedicine |
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| Outline of Annual Research Achievements |
The purpose of this research is to design and fabricate a carrier-free nanodrug via templated-crystallization method using SN-38, the active metabolite of irinotecan, acts as a potent inhibitor of DNA topoisomerase I. In this work, several derivatives of SN-38 were selected as the anticancer moiety, and Au cluster of ca. 10 nm was selected as a template. The nanodrugs are fabricated by reprecipitation method.
The formation yield of the hybrid nanodrugs were improved by adjusting the reprecipitation conditions, such as the good solvent of Au nanoparticles. The morphology of Au/SN-38Chol nanoparticles was confirmed SEM and showed a narrow size distribution and template-guided shape. Photothermal effect was investigated and exhibited a sufficient performance in comparison to pure Au nanoparticles.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
The second targets of the research plan are close to being complete, including observation of charge transfer effect between noble metal nanoparticles and drug molecules. The research is progressing to the profiling of the drug release kinetic at different conditions.
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| Strategy for Future Research Activity |
The next targets of the research are investigation of charge transfer effect by UV-Vis, XPS, and FT-IR. The results are correlated with the drug release rate and composition of SN-38 hybrid NPs.
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| Causes of Carryover |
A small amount of budget was transferred to the next fiscal year for some small equipment and materials that could not be purchased due to limited supplies.
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