Elucidation of the tumor-suppressive mechanism driven by FGF21-mediated cell comopetition

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K15098
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 44010:Cell biology-related
• Research Institution: The University of Tokyo
• Principal Investigator: Ogawa Motoyuki 東京大学, 大学院薬学系研究科(薬学部), 特任研究員 (10903198)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 細胞競合 / FGF21 / 発がん / 細胞間相互作用 / 細胞死

Outline of Final Research Achievements

Cell competition is a phenomenon in which cells with different properties compete for survival. Recently, it has been shown that cancerous cells are eliminated from normal tissues through cell competition in the early stages of cancer development, highlighting it as a novel endogenous tumor-suppressive mechanism. In this study, we established a new in vivo cell competition model that enables the easy and rapid induction of cell competition in the livers of normal mice. Furthermore, we demonstrated that FGF21, identified as a regulator of cell competition in vitro, induces cell competition in vivo.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

本研究で構築した簡便かつ迅速なin vivo細胞競合解析系は、生体内の細胞競合を活性化する創薬開発を目的としたin vivo創薬スクリーニングのための新規プラットフォームになる可能性がある。また、FGF21による細胞競合を活性化することで競合的細胞間相互作用によるがん変異細胞の排除を促進する新規がん治療戦略を提示した。