Molecular basis of supercompetition induced by Hippo pathway mutations

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K15102
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 44010:Cell biology-related
• Research Institution: Kyoto University
• Principal Investigator: Nagata Rina 京都大学, 生命科学研究科, 特定助教 (80912493)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: スーパーコンペティション / 細胞死 / オートファジー / ショウジョウバエ / bantam

Outline of Final Research Achievements

Yorkie(Yki)-activated cells stimulates cell proliferation and survival, as well as non-autonomous induction of cell death in surrounding cells in Drosophila epithelium, which is called 'super-competition'. Previously, we found that Yki-activated cells activate TOR signaling via microRNA bantam, which is required for cell death in surrounding wild-type cells. Importantly, bantam-overexpressing cells is sufficient to cause super-competition, while TOR activation is not sufficient. In this study, we dissected the mechanism by which bantam induces cell death in wild-type cells.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

スーパーコンペティションを引き起こす十分条件を明らかにできれば、これを人為的に制御することで新たながん治療戦略の基盤を構築できる可能性がある。さらには本研究を推進することで、組織中の適応度の高い細胞が低い細胞を排除するといった新たな組織恒常性維持の分子基盤を明らかにすることができる。