• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2023 Fiscal Year Final Research Report

Creation of New Lead Compounds using Natural Resources and Metal Nanoparticle Catalysts

Research Project

  • PDF
Project/Area Number 22K15252
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Research InstitutionOsaka University

Principal Investigator

Sirimangkalakitti Natchanun  大阪大学, 大学院薬学研究科, 特任助教 (10909120)

Project Period (FY) 2022-04-01 – 2024-03-31
Keywordsnatural product extract / chemical diversification / metal catalyst / lead compound
Outline of Final Research Achievements

We have developed a methodology for creating and discovering new biologically active compounds using natural resources and highly reactive metal nanoparticle catalysts. Our approach uniquely employs nanoparticle catalysts, such as Pd, to efficiently catalyze C-H bond activation, C-C cleavage, and cross-coupling reactions, facilitating the formation of new natural product-like compounds in one step. Our research successfully demonstrated the direct chemical diversification of natural product extracts from marine sponges, leading to the discovery of a new compound, rac-6-OEt-cylindradine A. These findings underscore the potential of our method for faster and more efficient drug discovery and development. We are further enhancing this methodology by developing highly reactive Rh nanoparticle catalysts. Research Achievements: two peer-reviewed publications and two conference presentations, one at an international conference

Free Research Field

Natural Product Drug Discovery and Development

Academic Significance and Societal Importance of the Research Achievements

Our research advances drug discovery by using metal nanoparticle catalysts to create new biologically active compounds from natural product extracts. This innovative approach accelerates pharmaceutical development, offering potential treatments for various diseases.

URL: 

Published: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi